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what is 5F ADB

To begin, 5F-ADBis a synthetic cannabinoid receptor agonist (SCRA) also with an aminoalkylindazole structure used as an active ingredient of products sold as cannabis substitutes. Synthetic canabis has no known therapeutic or medical use. In different regions it is being used and abusedfor non-medical purposes. Furthermore,some countries have put 5F-ADB under national control. When smoked, K2 produces cannabimimetic effects like Δ9-tetrahydrocannabinol (THC). Doses needed to produce these effects are lower than for THC. Many of the risks linked to cannabis use are also present in the case of 5F-ADB. Among the complications in patients suffering from cardiovascular diseases and triggering of acute psychosis.

Chemistry of this product 5F ADB

IUPAC Name:methyl-S-2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate
CA Index Name:n/a
Molecular Formula:C20H28FN3O3
Molecular Weight:377.46g/mo

General Pharmacology of 5F ADB

Herbal incense is a synthetic cannabinoid receptor agonist (SCRA). It has an indazole core, which is a common structural feature in a number of the SCRAs monitored by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA)and the UNODC.

Routes of administration and dosage

K2 is mainly offered on the Internet either in the form of ‘herbal mixtures’, where the chemical has been sprayed on plant material, as a powder, or in a liquid to be used in e-cigarette devices. Based on user reports and on the dosage forms offered, the primary route of administration is inhalation either by smoking the ‘herbal mixture’ as a joint or utilizing a vaporizer, or vaping through an e-cigarette. The effects of 5F-ADB are felt on doses as small as 50 microgramson cigarettesor buds.12Users reported strong cannabimimetic effects after smoking the drug.


present a case of an acute and fatal intoxication with 5F-ADB and diphenidine.Using LC/Q-TOFMS they could detect 3 metabolites of 5F-ADB in postmortem urine. First ester hydrolysis (M1) takes place, followed by oxidative defluorination (M2) and further oxidation to the carboxylic acid (M3). Although oxidative defluorinationas a first step could notbe excluded, no such substancecould be detected in this case.


There are no published pre-clinical safety data available concerning the toxicity,reproductive impact and carcinogenic/mutagenic potential of 5F-MDMB-PINACA.

The most common way of using it is by smoking a joint or vaping through an e-cigarette. Because these products rarely state the ingredients, most users will be unaware that they are using this product. Users of Spice may include recreational users, high-risk drug users, and groups who experiment with the substance (such as psychonauts). Furthermore,individuals who are subject to drug testing (such as people in drug treatment, prisoners, and drivers) may use 5F-ADB because routine drug tests/screens will be unable to detect SCRAs

Additional information


50g, 100g, 500g, 1000g


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